Autoantibodies to beta-amyloid and neurotransmitters in patients with Alzheimer's disease and senile dementia of the Alzheimer type

M A Myagkova; S I Gavrilova; N N Lermontova; Y B Kalyn; N D Selezneva; G A Zharikov; I V Kolykhalov; T V Abramenko; T P Serkova; S O Bachurin

doi:10.1023/a:1017527508878

Autoantibodies to beta-amyloid and neurotransmitters in patients with Alzheimer's disease and senile dementia of the Alzheimer type

Bull Exp Biol Med. 2001 Feb;131(2):127-9. doi: 10.1023/a:1017527508878.

Authors

M A Myagkova¹, S I Gavrilova, N N Lermontova, Y B Kalyn, N D Selezneva, G A Zharikov, I V Kolykhalov, T V Abramenko, T P Serkova, S O Bachurin

Affiliation

¹ Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.

PMID: 11391392
DOI: 10.1023/a:1017527508878

Abstract

The content of autoantibodies to beta-amyloid protein Abeta(1-42), its neurotoxic fragment Abeta(25-35), and neurotransmitters were studied in the blood of patients with presenile Alzheimer's disease and senile dementia of the Alzheimer type. Significant differences in the relative content of autoantibodies to Abeta(1-42)and autoantibodies to biogenic amines were demonstrated. These results can be used for the development of a biochemical method for differential diagnosis of Alzheimer dementias.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alzheimer Disease / classification
Alzheimer Disease / diagnosis
Alzheimer Disease / immunology*
Amyloid beta-Peptides / blood
Amyloid beta-Peptides / immunology*
Amyloid beta-Peptides / metabolism
Analysis of Variance
Autoantibodies / blood*
Biogenic Monoamines / immunology*
Enzyme-Linked Immunosorbent Assay
Humans
Middle Aged
Peptide Fragments / blood
Peptide Fragments / immunology*
Peptide Fragments / metabolism

Substances

Amyloid beta-Peptides
Autoantibodies
Biogenic Monoamines
Peptide Fragments
amyloid beta-protein (1-42)
amyloid beta-protein (25-35)