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Angioedema After Local Trauma in a Patient on Angiotensin-Converting Enzyme Inhibitor Therapy

Section of Geriatric Medicine, Temple University, Philadelphia, PA (BBS)
Calvert Family Practice Associates, Prince Frederick, MD (MAF)
Department of Family Medicine, Oregon Health and Science University, Portland (LAB)
Department of Family and Community Medicine, Thomas Jefferson University, Philadelphia, PA (JSS)

Correspondence: Corresponding author: B. Brent Simmons, Temple University Geriatrics, 1316 W. Ontario Street, Philadelphia, PA 19140 (E-mail: b.brent.simmons{at}tuhs.temple.edu)

Angioedema is a side effect that is often associated with the use of angiotensin-converting enzyme (ACE) inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE inhibitor therapy, resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE inhibitor.

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